Antisense oligodeoxynucleotide compounds (AS ODN) are being developed as therapeutics
for various disease indications. Their safety and pharmacokinetics are most commonly …

… Meg Ferrell Ramos, Co-Chair, 1, a, * Julia Baker, Co-Chair, 2, a Elke-Astrid Atzpodien, 3, a
Ute Bach, 4, a Jacqueline Brassard, 5, a James Cartwright, 6, a Cynthia Farman, 7, a Cindy …

… exposure C max , whereas the ‘burst’ effect seen with some polymer LAD technologies
can provide a useful local loading dose, but are also expected to produce a higher C max …

… The microsphere doses were stored at 2 to 8C until shipment. The particles produced
were characterized for bioburden and endotoxin content, the particle size distribution was …

… Briefly, tissues were submerged in RNA later and allowed to equilibrate overnight at 4 C
before being frozen at −80 C. Total RNA was extracted from frozen cell pellets using the …

Recent attempts 1,2 to consolidate assessments of the effect of human activities on stratospheric
ozone (O 3 ) using one-dimensional models for 30 N have suggested that perturbations …

Seven Pacific harbor seals with meningoencephalitis associated with Sarcocystis neurona-like
protozoa are described. Six of the 7 seals were free-ranging and were found stranded …

Objective —To determine the distribution for limbs and bones in horses with fractures of the
proximal sesamoid bones and relationships with findings on palmarodorsal radiographic …

Denosumab is a monoclonal antibody that inhibits bone resorption by targeting RANKL, an
essential mediator of osteoclast formation, function, and survival. Reproductive toxicity of …

… N1 OE was produced by incubation of N1 at 50C for six days followed by 10 freeze/thaw
cycles. It was included in this study so that effects due to oligomerization of the N1 protein (a …