Detection of genetic variants in clinically relevant genomic hot-spot regions has become a
promising application of next-generation sequencing technology in precision oncology. …

Alpha-toxin, the major cytotoxic agent elaborated by Staphylococcus aureus, was the first
bacterial exotoxin to be identified as a pore former. The protein is secreted as a single-chain, …

Innovation is the sole driver of productivity—and with it, growth across all asset classes. But
the asset class in charge of financing innovation is in trouble: Conventional VC has failed to …

Mammalian cell membranes consist of single bilayers of lipid with integral membrane
proteins inserted into the bitayer and more loosely associated peripheral membrane proteins. …

… J. Wellensiek provided the excellent laboratory facilities in Giessen which rendered
completion of this work possible. The technical assistance of Dorothea Sziegoleit, Barbara H6nig, …

Following entrapment in the arterial intima, low-density lipoprotein (LDL) can be modified by
hydrolytic enzymes to yield a lipoprotein derivative that binds C-reactive protein, activates …

Staphylococcal alpha-toxin was radiolabeled to high specific radioactivity (1,500-3,000 Ci/mmol)
under retention of its hemolytic activity. Binding studies with susceptible rabbit …

Native staphylococcus aureus alpha-toxin is secreted as a hydrophilic polypeptide chain of
Mr 34,000. The presence of deoxycholate above the critical micellar concentration induced …

Mitogen activated protein kinase (MAPK) p38 has emerged as a survival protein in cells that
are attacked by bacterial toxins forming small membrane pores. Activation of p38 by pore …

Helicobacter pylori infects up to 50% of the human population worldwide. The infection occurs
predominantly in childhood and persists for decades or a lifetime. H. pylori is believed to …