[HTML][HTML] Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

…, JA Brody, EG Burchard, BE Cade, JF Casella… - Nature, 2021 - nature.com
The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …

[HTML][HTML] Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls

AB Bruner, A Joffe, AK Duggan, JF Casella, J Brandt - The Lancet, 1996 - thelancet.com
Background Up to 25% of adolescent girls in the USA are iron deficient. This double-blind,
placebo-controlled clinical trial assessed the effects of iron supplementation on cognitive …

Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG)

WC Wang, RE Ware, ST Miller, RV Iyer, JF Casella… - The Lancet, 2011 - thelancet.com
Background Sickle-cell anaemia is associated with substantial morbidity from acute
complications and organ dysfunction beginning in the first year of life. Hydroxycarbamide …

A general amphipathic α-helical motif for sensing membrane curvature

G Drin, JF Casella, R Gautier, T Boehmer… - Nature structural & …, 2007 - nature.com
The Golgi-associated protein ArfGAP1 has an unusual membrane-adsorbing amphipathic α-helix:
its polar face is weakly charged, containing mainly serine and threonine residues. We …

[HTML][HTML] Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia

…, MA Kraut, WS Ball Jr, D Hirtz, JF Casella - … England Journal of …, 2014 - Mass Medical Soc
Background Silent cerebral infarcts are the most common neurologic injury in children with
sickle cell anemia and are associated with the recurrence of an infarct (stroke or silent …

Cytochalasin D inhibits actin polymerization and induces depolymerization of actin filaments formed during platelet shape change

JF Casella, MD Flanagan, S Lin - Nature, 1981 - nature.com
Cytochalasins, a class of fungal metabolites, affect a wide variety of motile functions of
eukaryotic cells 1–3 . Recently, several laboratories have shown that cytochalasins inhibit actin …

ArfGAP1 responds to membrane curvature through the folding of a lipid packing sensor motif

J Bigay, JF Casella, G Drin, B Mesmin… - The EMBO journal, 2005 - embopress.org
ArfGAP1 promotes GTP hydrolysis in Arf1, a small G protein that interacts with lipid membranes
and drives the assembly of the COPI coat in a GTP‐dependent manner. The activity of …

[HTML][HTML] Results of minimally toxic nonmyeloablative transplantation in patients with sickle cell anemia and β-thalassemia

R Iannone, JF Casella, EJ Fuchs, AR Chen… - Biology of Blood and …, 2003 - Elsevier
We describe previously transfused patients with sickle cell disease (n = 6) and thalassemia (n
= 1) who received nonmyeloablative hematopoietic stem cell transplantation (HCT) to …

Silent cerebral infarcts occur despite regular blood transfusion therapy after first strokes in children with sickle cell disease

…, JF Casella, B Inusa, J Howard… - Blood, The Journal …, 2011 - ashpublications.org
Children with sickle cell disease (SCD) and strokes receive blood transfusion therapy for
secondary stroke prevention; despite this, approximately 20% experience second overt strokes. …

Risk of recurrent stroke in children with sickle cell disease receiving blood transfusion therapy for at least five years after initial stroke

…, JY Chu, CH Pegelow, W Wang, JF Casella… - The Journal of …, 2002 - Elsevier
Objective: To test the hypothesis that children with sickle cell disease (SCD) who have an
initial stroke temporally unrelated to another medical event are at higher risk for recurrent …