The role of the CD28 receptor during T cell responses to antigen

PS Linsley, JA Ledbetter - Annual review of immunology, 1993 - annualreviews.org
The CD28 receptor is stimulated during the contact of T cells with antigenн presenting cells.
A counter-receptor for CD28 is the B7 molecule expressed on activated B cells, dendritic …

Role of the CD28 receptor in T-cell activation

CH June, JA Ledbetter, PS Linsley, CB Thompson - Immunology today, 1990 - cell.com
Antigen-specific T-ceil activation is initiated through the T-cell receptor. Recent evidence has
shown that a number of additional T-cell surface receptors serve to regulate the responses …

How B and T cells talk to each other

EA Clark, JA Ledbetter - Nature, 1994 - nature.com
The B cells of the immune system, which secrete antibodies against foreign antigens, are
fully specific and effective only after maturation in lymph nodes and other lymphoid tissues. …

A two-question method for assessing gender categories in the social and medical sciences

CC Tate, JN Ledbetter, CP Youssef - Journal of sex research, 2013 - Taylor & Francis
Three studies (N = 990) assessed the statistical reliability of two methods of determining
gender identity that can capture transgender spectrum identities (ie, current gender identities …

CTLA-4 is a second receptor for the B cell activation antigen B7.

…, LS Grosmaire, NK Damle, JA Ledbetter - The Journal of …, 1991 - rupress.org
… Aruffo, NK Damile, and JA Ledbetter. 1991. Binding of the B cell activation antigen B7 to …
Ledbetter. 1988. Differential regulatory signals delivered by antibody binding to the CD28 (…

The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma

…, J Raycraft, M Hayden-Ledbetter, JA Ledbetter… - Cancer research, 2003 - AACR
The WFDC2 (HE4) gene is amplified in ovarian carcinomas, whereas its expression in normal
tissues, including ovary, is low. Although the function of the HE4 protein is unknown,it is a …

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

…, JAL Greene, W Brady, J Bajorath, JA Ledbetter… - Immunity, 1994 - cell.com
B7-0 or B7-2 (CD86) is a T cell costimulatory molecule that binds the same receptors (CD28
and CTLA-4) as B7-1 (CD80), but shares with it only ∼25% sequence identity and is …

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

…, A Aruffo, NK Damle, JA Ledbetter - The Journal of …, 1991 - rupress.org
A successful immune response requires intercellular contact between T and B lymphocytes.
We recently showed that CD28, a T cell surface protein that regulates an activation pathway, …

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

…, SS De Ravin, CK Smith, HL Malech, JA Ledbetter… - Nature medicine, 2016 - nature.com
Neutrophil extracellular traps (NETs) are implicated in autoimmunity, but how they are
generated and their roles in sterile inflammation remain unclear. Ribonucleoprotein immune …

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

…, WA Brady, I Hellström, KE Hellström, JA Ledbetter… - Cell, 1992 - cell.com
Interaction of the B7 molecule on antigen-presenting cells with its receptors CD28 and CTLA-4
on T cells provides costimulatory signals for T cell activation. We have studied the effects …