Targeting glioma stem cells through combined BMI1 and EZH2 inhibition
Glioblastomas are lethal cancers defined by angiogenesis and pseudopalisading necrosis.
Here, we demonstrate that these histological features are associated with distinct …
Here, we demonstrate that these histological features are associated with distinct …
Transcription elongation factors represent in vivo cancer dependencies in glioblastoma
Glioblastoma is a universally lethal cancer with a median survival time of approximately 15
months 1 . Despite substantial efforts to define druggable targets, there are no therapeutic …
months 1 . Despite substantial efforts to define druggable targets, there are no therapeutic …
[HTML][HTML] Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches
Glioblastoma (GBM) displays marked cellular and metabolic heterogeneity that varies among
cellular microenvironments within a tumor. Metabolic targeting has long been advocated …
cellular microenvironments within a tumor. Metabolic targeting has long been advocated …
[HTML][HTML] Nicotinamide metabolism regulates glioblastoma stem cell maintenance
…, T Sanvoranart, CG Hubert, BC Prager, LC Wallace… - JCI insight, 2017 - ncbi.nlm.nih.gov
… (B–I) Metabolite analysis by specific assay kits and liquid chromatography-mass spectrometry
(LC-MS/MS) (E and I) in GSCs vs. DTCs. LC-MS/MS was performed with 1 × 10 7 cells for …
(LC-MS/MS) (E and I) in GSCs vs. DTCs. LC-MS/MS was performed with 1 × 10 7 cells for …
[HTML][HTML] Three-dimensional organoid culture unveils resistance to clinical therapies in adult and pediatric glioblastoma
Background Glioblastoma (GBM) is the most common primary brain tumor with a dismal
prognosis. The inherent cellular diversity and interactions within tumor microenvironments …
prognosis. The inherent cellular diversity and interactions within tumor microenvironments …
The meningioma enhancer landscape delineates novel subgroups and drives druggable dependencies
…, D Dixit, JA Bernatchez, Q Wu, LC Wallace… - Cancer discovery, 2020 - AACR
Enhancer landscapes inform prognostic classification of aggressive meningiomas, identifying
tumors at high risk of recurrence, and reveal previously unknown therapeutic targets. …
tumors at high risk of recurrence, and reveal previously unknown therapeutic targets. …
[HTML][HTML] Young Mothers and Dating Violence: An Examination of Depressive Symptomatology and Interpersonal Competency
Purpose Young mothers are an understudied group at high risk for dating violence (DV)
victimization and perpetration. Prior research has investigated depressive symptomatology as a …
victimization and perpetration. Prior research has investigated depressive symptomatology as a …
Characterization of recombinant human prorenin and renin.
CT Carilli, JL Vigne, LC Wallace, LM Smith… - …, 1988 - Am Heart Assoc
A cell line that secretes substantial quantities of recombinant human prorenin was prepared
by transfecting Chinese hamster ovary cells with a gene encoding preprorenin. The prorenin …
by transfecting Chinese hamster ovary cells with a gene encoding preprorenin. The prorenin …
Effect of penitrem A on mouse liver composition
AW Hayes, RD Phillips, LC Wallace - Toxicon, 1977 - Elsevier
… WALLACE Department of Pharmacology and Toxicology, University of Mississippi Medical
… AW HAYEs, RD Ptuttws and LC WALLACE. Effect of penitrem A on mouse liver composition. …
… AW HAYEs, RD Ptuttws and LC WALLACE. Effect of penitrem A on mouse liver composition. …
A tubo-ovarian abscess mimicking an appendiceal abscess: a rare presentation of Streptococcus agalactiae
GM Taylor, AH Erlich, LC Wallace… - Oxford Medical Case …, 2019 - academic.oup.com
A tubo-ovarian abscess (TOA) is a relatively rare medical complication that results from an
untreated/unrecognized ascending pelvic infection of the female genital tract. In a right-sided …
untreated/unrecognized ascending pelvic infection of the female genital tract. In a right-sided …