An alternative route for the folding of large RNAs: apparent two-state folding by a group II intron ribozyme

LJ Su, M Brenowitz, AM Pyle - Journal of molecular biology, 2003 - Elsevier
Despite a growing literature on the folding of RNA, our understanding of tertiary folding in
large RNAs derives from studies on a small set of molecular examples, with primary focus on …

Resolving an isotopic boundary within the Australian-Antarctic Discordance

DG Pyle, DM Christie, JJ Mahoney - Earth and Planetary Science Letters, 1992 - Elsevier
… The `Indian' group data suggest that discrete melts of either 'Reunion' or `Kerguelen' type
contaminants mix with "depleted" Indian MORB melts en route to the surface. Similar isolated `…

An ultraprocessive, accurate reverse transcriptase encoded by a metazoan group II intron

C Zhao, F Liu, AM Pyle - Rna, 2018 - rnajournal.cshlp.org
… Recent crystallographic studies on members of this RT family have revealed that they … RT
family has been lacking. Here, we characterize the processivity of a group II intron maturase RT

Crystal structures of a group II intron maturase reveal a missing link in spliceosome evolution

C Zhao, AM Pyle - Nature structural & molecular biology, 2016 - nature.com
… 1b), we created an Er RT construct (1–293) spanning the same region as the Ri RT, and
we solved its structure to 2.1 Å (Table 1) by molecular replacement, using the Ri monomer as …

[HTML][HTML] Sequencing and structure probing of long RNAs using MarathonRT: a next-generation reverse transcriptase

…, CM Gallardo, BR Graveley, BE Torbett, AM Pyle - Journal of molecular …, 2020 - Elsevier
… Reverse transcriptase (RT) enzymes are … RT enzymes are now required for preserving
linkage and information content in mixed populations of transcripts, and the low-processivity RT

Kinship Care Programs: Effective Marketing and Outreach Build With Care and They Will Come!

RT Pyle, HL Lucas, D Variano - … Contemporary Journal of …, 2022 - scholarworks.wmich.edu
… , financial assistance, and educational support for the children in their care, relative caregivers
have identified the support of other kinship caregivers as a primary need (Cohen & Pyle, …

Disruption and Opportunity: Utility Deregulation and the Potential for Private Equity Investment

TR Crockett, RT Pyle - The Journal of Private Equity, 1999 - JSTOR
Deregulation is radically altering the utilities landscape, creating opportunities among the
giant monopolies for newcomers to provide select products and services to the industry. These …

Multilaboratory comparison of hepatitis C virus viral load assays

…, GJ Tsongalis, R Pyles… - Journal of clinical …, 2006 - Am Soc Microbiol
RT-… RT-PCR assay was, on average, 0.15 log 10 lower than that of the Bayer bDNA. Based
on these data, we conclude that the sensitivity and linear range of the Abbott and Roche RT-…

Tissue distribution of opioid receptor gene expression in the rat

G Wittert, P Hope, D Pyle - Biochemical and biophysical research …, 1996 - Elsevier
… We did not detect δ opioid receptor expression in the cerebellum by RT-PCR in this study.
Very low levels of δ opioid receptor mRNA have been detected in the rat cerebellum by …

Dieckmann cyclization as a route to a-nor steroids. Evidence concerning stereochemistry

JL Pyle, BV Paranjape - The Journal of Organic Chemistry, 1971 - ACS Publications
The value of 3 supports a ß configuration for the hydroxyl group. Thefact that only a small
change, 0.12 ppm upfield, is observed for the ß-keto ester in pyridine and that this difference is …