… ‘C′ grade formulations retained solvation capacity on dispersion but resulted in drug
precipitation on initiation of digestion. ‘B′ grade formulations retained solubilisation through …

Poorly water-soluble drugs continue to be a problematic, yet important class of pharmaceutical
compounds for treatment of a wide range of diseases. Their prevalence in discovery is …

Preformulation measurements are used to estimate the fraction absorbed in vivo for orally
administered compounds and thereby allow an early evaluation of the need for enabling …

Materials and Methods The present investigation is an update on a prospective multicenter
trial that examined outcomes after 5 years. 14 At the completion of the study, the clinical …

… A majority of the implants had been placed into arch shape groups B, C, or D and into Type
3 or 4 bone quality (Table 2). A standardized surgical technique was used when placing the …

… The plates were thereafter incubated in jars for 7 days at 37C, using hydrogen combustion in
… Enterococci medium (BBL Microbiological Systems) and incubated for 3 days in air at 37C. …

… C will inhibit the transport by 50% at a concentration 9 × C. If the sigmoidal relationship
has a steeper slope of, say, 3, the compound will give 50% inhibition at a concentration 2.1 × …

… between the solubility values measured at 25 and 37 C (Figure 5). These results suggest
that … PSA b (Å 2 ) NPSA b (Å 2 ) predicted S class c predicted P app class c theoretical BCS c …

This Review describes some of the approaches and techniques used today to derive in
silico models for the prediction of ADMET properties. The article also discusses some of the …

… The excess solid was dried at 60 C overnight. Amiodarone, which was studied with … and
heated at a rate of 10 C/min in the interval 25–350 C. The thermograms were used to identify …