The challenge of atropisomerism in drug discovery
A twist in the tale: Recent reports have highlighted solutions to the problems encountered
when drug candidates exist as slowly interconverting conformers or atropisomers (see scheme)…
when drug candidates exist as slowly interconverting conformers or atropisomers (see scheme)…
Assessing atropisomer axial chirality in drug discovery and development
…, R Kemper, SPF Miller, PJ Edwards - Journal of medicinal …, 2011 - ACS Publications
An underlying goal of drug discovery is to develop safe and stable substances that specifically
target essential elements that cause disease. Molecular chirality adds an additional level …
target essential elements that cause disease. Molecular chirality adds an additional level …
[PDF][PDF] Oral lichen planus: clinical presentation and management
PC Edwards, R Kelsch - 2002 - scholarworks.iupui.edu
Le lichen plan est une affection chronique de la muqueuse qui s’ observe fréquemment en
cabinet. Le lichen plan serait le résultat d’une réaction immunitaire anormale au cours de …
cabinet. Le lichen plan serait le résultat d’une réaction immunitaire anormale au cours de …
[BOOK][B] A vast machine: Computer models, climate data, and the politics of global warming
PN Edwards - 2013 - books.google.com
… In A Vast Machine Paul Edwards has news for these skeptics: without models, there are no
… Edwards offers an engaging and innovative history of how scientists learned to understand …
… Edwards offers an engaging and innovative history of how scientists learned to understand …
[BOOK][B] The closed world: Computers and the politics of discourse in Cold War America
PN Edwards - 1996 - books.google.com
… metaphors and political icons, Paul Edwards shows how Cold War … Edwards begins by
describing the emergence of a" closed-… Edwards then shows how these military projects helped …
describing the emergence of a" closed-… Edwards then shows how these military projects helped …
Infrastructure studies meet platform studies in the age of Google and Facebook
JC Plantin, C Lagoze, PN Edwards… - New media & …, 2018 - journals.sagepub.com
Two theoretical approaches have recently emerged to characterize new digital objects of
study in the media landscape: infrastructure studies and platform studies. Despite their …
study in the media landscape: infrastructure studies and platform studies. Despite their …
Infrastructure and modernity: Force, time, and social organization in the history of sociotechnical systems
PN Edwards - Modernity and technology, 2003 - direct.mit.edu
The argument of this essay is that infrastructures simultaneously shape and are shaped by—in
other words, co-construct—the condition of modernity. By linking macro, meso, and micro …
other words, co-construct—the condition of modernity. By linking macro, meso, and micro …
Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing
Human cancers often carry many somatically acquired genomic rearrangements, some of
which may be implicated in cancer development. However, conventional strategies for …
which may be implicated in cancer development. However, conventional strategies for …
Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin
…, JA Smith, D Stirling, PR Edwards… - Journal of the …, 2010 - ACS Publications
The platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin are an important
component of chemotherapy but are limited by severe dose-limiting side effects and the …
component of chemotherapy but are limited by severe dose-limiting side effects and the …
Complex multi-enhancer contacts captured by genome architecture mapping
… by their mean P i3 and selected the top 2%. To predict TAD triplets using pairwise P i values
… to the minimum average P i calculated between all pairs of TADs that is, min(P iAB , P iAC , …
… to the minimum average P i calculated between all pairs of TADs that is, min(P iAB , P iAC , …