A twist in the tale: Recent reports have highlighted solutions to the problems encountered
when drug candidates exist as slowly interconverting conformers or atropisomers (see scheme)…

An underlying goal of drug discovery is to develop safe and stable substances that specifically
target essential elements that cause disease. Molecular chirality adds an additional level …

Le lichen plan est une affection chronique de la muqueuse qui s’ observe fréquemment en
cabinet. Le lichen plan serait le résultat d’une réaction immunitaire anormale au cours de …

… In A Vast Machine Paul Edwards has news for these skeptics: without models, there are no
… Edwards offers an engaging and innovative history of how scientists learned to understand …

… metaphors and political icons, Paul Edwards shows how Cold War … Edwards begins by
describing the emergence of a" closed-… Edwards then shows how these military projects helped …

Two theoretical approaches have recently emerged to characterize new digital objects of
study in the media landscape: infrastructure studies and platform studies. Despite their …

The argument of this essay is that infrastructures simultaneously shape and are shaped by—in
other words, co-construct—the condition of modernity. By linking macro, meso, and micro …

Human cancers often carry many somatically acquired genomic rearrangements, some of
which may be implicated in cancer development. However, conventional strategies for …

The platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin are an important
component of chemotherapy but are limited by severe dose-limiting side effects and the …

… by their mean P i3 and selected the top 2%. To predict TAD triplets using pairwise P i values
… to the minimum average P i calculated between all pairs of TADs that is, min(P iAB , P iAC , …