VNP20009 is a genetically modified strain of Salmonella typhimurium possessing an excellent
safety profile, including genetically stable attenuated virulence (a deletion in the purl gene…

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently
associated with poor prognosis, particularly in high-risk patients. The cornerstones in the …

Background. Escherichia coli sequence type 131 (ST131), typically fluoroquinolone-resistant
(FQ-R) and/or extended-spectrum β-lactamase (ESBL)–producing, has emerged globally. …

In the last three decades, Clostridium difficile infection (CDI) has increased in incidence and
severity in many countries worldwide. The increase in CDI incidence has been particularly …

Estimates of antibacterial activity can be determined using a wide variety of different in vitro
methods. These include manual methods such as disk diffusion, broth microdilution, and …

… (SM Brecher, unpublished data). This reduction in test volume was achieved through
educational seminars and meetings with the medical/surgical staff. Kaiser Permanente in Southern …

In the last two decades there have been dramatic changes in the epidemiology of Clostridium
difficile infection (CDI), with increases in incidence and severity of disease in many …

Background Antimicrobial Stewardship Programs (ASPs) have been promoted to optimize
antimicrobial usage and patient outcomes, and to reduce the emergence of antimicrobial-…

BACKGROUND Although optimal utilization of blood cultures has been studied in populations,
including emergency room and intensive care patients, less is known about the use of …

Fluorescence in situ hybridization (FISH) using peptide nucleic acid (PNA) probes targeting
Staphylococcus aureus 16S rRNA is a novel method for direct identification of S. aureus from …